Comparative study of Novel Silicate & Borate Bioglass Hydrogels for Skin Tissue Regeneration
Skin tissue Engineering is a viable branch of Tissue Engineering. In the late 1970, skin tissue engineering was only perceived for the development of tissue cultures (i.e., cultivation of cells, tissues, or organs on specially formulated nutrient media). But from 1980 onwards, engineered s
Project Title
Comparative study of Novel Silicate & Borate Bioglass Hydrogels for Skin Tissue Regeneration
Project Area of Specialization
Project Summary
Skin tissue Engineering is a viable branch of Tissue Engineering. In the late 1970, skin tissue engineering was
only perceived for the development of tissue cultures (i.e., cultivation of cells, tissues, or organs on specially formulated nutrient media). But from 1980 onwards, engineered skin was seen as a potential clinical product. Nowadays hydrogel fabrication is one of the leading applications for skin tissue engineering. A hydrogel is a cross-linked hydrophilic polymer, that are highly water absorbent yet they maintain well defined shape, structure and moisture. They can be easily modified within the polymer matrix, they have high water content, controllable swelling behavior, and they are biocompatible as well. For our project we intend to fabricate novel Polymer based bioactive hydrogel by incorporation of in-house fabricated modified 1393 (silicate) and 1393 B3 (borate) bioglass (BG). Our goal is to comparatively investigate the effect of pure and modified silicate and borate bioglass on Polymer based hydrogels. Polymer based hydrogels have a wide range of applications in the biomedical field because of their biocompatibility, biodegradability, and good mechanical properties. The Polymer used as a base material will be inexpensive, readily available, and can easily be modified. The properties of the polymer can easily be manipulated by the addition of different materials. As Polymer is bioinert, so in order to generate bioactivity in polymer matrix we will incorporate bioactive glass with modified compositions to comparatively investigate the impact of novel silicate and borate bioglass in Polymer hydrogels. Subsequently various in – vitro tests will perform to characterize the fabricated samples.
Project Objectives
1. To fabricate and characterize bioactive Polymer based hydrogels for its chemical, mechanical, physical and thermal properties.
2. To compare the impact of silicate and borate bioglass on Polymeric hydrogel based on aforementioned properties.
Project Implementation Method
Our project implementation will involve following steps:
1. Fabrication of Silicate and Borate Bioglass (Pure & Modified).
2. Characterization of Silicate and Borate Bioglass (Pure & Modified).
3. Fabrication of Hydrogels (Composite Scaffolds of Bioglass).
4. Characterization of Hydrogels (Composite Scaffold of Bioglass).
Benefits of the Project
This study will provide an effective and low-cost skin regeneration substitute for clinical use. Our engineered composite may be used for patients suffering from skin injuries to support regeneration of the skin tissues as
it has the ability to degrade at controllable rates and has increased bioactivity. Our hydrogel composite material will be effective for wound healing, wound dressing and for better wound closure as it is expected to have good mechanical strength due to incorporation of bioglass. Hence with these elevated characteristics, our composite scaffolds truly stand out and will have great potential towards healthcare sectors.
Technical Details of Final Deliverable
Our proposed project will be a step towards strengthening and upgradation of the properties of the hydrogel. We expect that the end product of our project will be Polymer-BG based composite sample that will exhibit improved mechanical strength due to the presence of Polymer and excellent bioactivity, biodegradability and hydrophilicity due to the incorporation of bioglass. And together all these aspects will accelerate tissue regeneration.
Final Deliverable of the Project
Core Industry
Other Industries
Core Technology
Other Technologies
Sustainable Development Goals
Required Resources
| Item Name | Type | No. of Units | Per Unit Cost (in Rs) | Total (in Rs) |
|---|---|---|---|---|
| Sodium nitrate | Equipment | 1 | 800 | 800 |
| Magnesium nitrate hexa hydrate | Equipment | 1 | 1900 | 1900 |
| Calcium nitrate tetra hydrate | Equipment | 1 | 1800 | 1800 |
| Potassium nitrate | Equipment | 1 | 650 | 650 |
| TEOS | Equipment | 1 | 5850 | 5850 |
| TEP | Equipment | 1 | 8450 | 8450 |
| Beaker 200 ml | Equipment | 1 | 120 | 120 |
| Beaker 100 ml | Equipment | 2 | 70 | 140 |
| Spatula | Equipment | 1 | 120 | 120 |
| Boric acid | Equipment | 1 | 600 | 600 |
| Aluminium foil | Equipment | 1 | 300 | 300 |
| Paper tape | Equipment | 1 | 60 | 60 |
| Universal containers | Equipment | 15 | 25 | 375 |
| Silicon molds | Equipment | 10 | 176 | 1760 |
| Latex gloves box | Equipment | 1 | 860 | 860 |
| Sodium Chloride (NaCl) | Equipment | 1 | 800 | 800 |
| Sodium Bicarbonate (NaHCO3) | Equipment | 1 | 900 | 900 |
| Potassium Chloride (KCL) | Equipment | 1 | 1200 | 1200 |
| Di-potassium hydrogen phosphate trihydrate (K2HPO4.3H2O) | Equipment | 1 | 1800 | 1800 |
| Magnesium chloride hexahydrate (MgCl2.6H2O) | Equipment | 1 | 1400 | 1400 |
| Sodium Sulfate (Na2SO4) | Equipment | 1 | 1500 | 1500 |
| Antibacterial Test (5 samples) | Equipment | 5 | 1200 | 6000 |
| Printing and binding | Miscellaneous | 1 | 3000 | 3000 |
| DVDs | Miscellaneous | 1 | 2000 | 2000 |
| Total in (Rs) | 42385 |
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