Synthesis of Magnesium Aluminium layered double hydroxide and Silver Nanoparticles for antibacterial drug delivery

The purpose of current research is to design magnesium (Mg) and Aluminium (Al) layered double hydroxide silver Nano particles(Ag Np's) based nano-composite for antibacterial drug delivery in order to treat various antibacterial infectious diseases and to improve the drug efficien

Project Title

Synthesis of Magnesium Aluminium layered double hydroxide and Silver Nanoparticles for antibacterial drug delivery

Project Area of Specialization

Biomedical Engineering

Project Summary

The purpose of current research is to design magnesium (Mg) and Aluminium (Al) layered double hydroxide silver Nano particles(Ag Np's) based nano-composite for antibacterial drug delivery in order to treat various antibacterial infectious diseases and to improve the drug efficiency and to achieve the controlled release property. The production of layered double hydroxide (LDH) nanocomposite is an alternative drug delivery system against various diseases. Synthesis of Mg/Al layered double hydroxide-Ag NPs based Nanocomposite could be an effective tool to use in antimicrobial applications and treatment. AgNPs coating will confer on the synergistic antimicrobial effects against microbes and thereby would increase the efficacy of the designed nanocomposite formulation. The key parameter in designing drug-delivery systems is their tendency to release the active agents (drugs/genes/ biomolecules, etc) in a sustained manner at the target site. This study reports on the development of a nanodelivery system that intercalates the anti-bacterial drug into Mg/Al layered double hydroxides LDHs.

Project Objectives

This project aims at developing a biocompatible and biodegradable nano system for drug delivery for sustained release of antibacterial drug for enhanced efficacy. We will design Mg/Al layered double hydroxide (nanolayers), coated with silver nanoparticles for antibacterial drug delivery system, which can work as a general purpose anti-bacterial substabce.

Project Implementation Method

Synthesis of Mg/Al layered double hydroxide-Ag NPs based Nanocomposite for  anti-bacterial drug

• In organic Nanolayers of Mg/Al layered double hydroxide-Ag NPs based Nanocomposite are prepared by ion exchange and co-precipitation method.
• anti -bacterial drug is intercalated into Mg/Al layered double hydroxide.
• • By these methods we prepared nano layers by using direct and indirect methods, after designing nano layers we have intercalated anti-bacterial drug in it.

Synthesized Mg/Al layered double hydroxide-Ag NPs based Nanocomposite for anti-bacterial drug will be characterized by following characterizing techniques to confirm whether it is successfully intercalated.

• X-Ray diffraction( XRD)  
• Field Emission Scanning Electron Microscope(FESEM)
• Transmission Electron Microscopy(TEM)
• Dynamic Light Scattering (DLS)
• Uv-visible spectrophotometer

In vitro and in vivo tests

• Further investigations on detailed cellular mechanism of Mg/Al layered double hydroxide-Ag NPs based Nanocomposite for antibacterial drug delivery will be conducted by different in vitro and in vivo tests (Cytotoxicity tests, cell viability assays, cell susceptibility tests, anti-bacterial release property, biocompatibility tests on normal cell lines).

Benefits of the Project

• Mg/Al layered double hydroxide-Ag NPs based Nanocomposite  is designed and  developed with antimicrobial properties to cure   many diseases which are caused by microbes.
• The antimicrobial drugs intercalated into this type of Mg/Al layered double hydroxide LDH would result in a collaborative antimicrobial effect.
• The designed Mg/Al layered double hydroxide-Ag NPs based Nanocomposite will be release the antimicrobial drug in a sustained manner.
• The nanodelivery Mg/Al layered double hydroxide-Ag NPs based Nanocomposite  will be 3× more biocompatible compared to the free antibacterial drug.
• Improved efficacy against bacteria because nano-size helps in bacterial penetration and silver nanoparticles in formulation will results synergistic antimicrobial effect.
• It is biocompatible with normal cells and tissues.
• Able to deliver the drug at the disease site.
• It is biodegradable and easily excreted from the body after releasing the drugs.
• Reduction in dosing frequency/dosage.
• It is less toxic as compared to other antibacterial drugs.
• Increase therapeutic efficacy.
• It is effective or productive in relation to its cost.
• The maximum response achievable from a pharmaceutical drug.
• The bioavailability of the drug is improved .

Technical Details of Final Deliverable

The foreseen final product is an anti bacterial drug delivery system. The drug is supposed to be intercalated between layered double hydroxide nanolayers, coated with silver nano particles. We aim to make drug more efficient by coating silver nano particles. Silver nanoparticles have been shown to have effective antibacterial activity against a range of disease-causing bacteria. We will develop a nano delivery system that intercalates the anti-Bacterial drug into Mg/Al layered double hydroxides (LDHs). Antibacterial will be released in a sustained manner from the novel nano- delivery system in human being .Commercially available anti-bacterial drugs have long treatment duration, high dosing frequency and adverse.

Final Deliverable of the Project

Hardware System

Core Industry

Medical

Other Industries

Health

Core Technology

Wearables and Implantables

Other Technologies

Others

Sustainable Development Goals

Good Health and Well-Being for People

Required Resources

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