Using Nanoparticles for coating of dental implants to enhance Osteointegration.

Project Title

Using Nanoparticles for coating of dental implants to enhance Osteointegration.

Project Area of Specialization Biomedical EngineeringProject Summary

Nanoparticles are suitable candidates for coating of Stainless steel based dental implants due to their unique properties such as biocompatibility, mechanical strength, low cost, availability and great corrosion resistance. All these properties aid to greater durability and sustainability. Dental implant has demonstrated clinical success over recent years despite its major problem due to implant fixation that leads to bacterial infection and rejection of the implant. Recently, nanoparticle-coatings have been reported to have beneficial properties to improve implant fixation and increase the success rate. Out project aim to use coating of Cerium Oxide Nanoparticles implant surface in order increase the functionality, improve the

stability and fixation of the implant. Also, it shall enhance Osseo-integration and Antimicrobial Property of the implant which collectively makes the implant market competitive & successful.

Project Objectives

The main 3 Objectives of Our project:

1. Synthesis of Cerium Oxide Nanoparticles.
2. Successful  Deposition Of Nanoparticles On Stainless Steel 316L.
3. Efficiency Test By Means Of Various Tests.

Project Implementation Method

Initially selection of suitable material as implant i.e Sheet of 316 Stainless steel on which coating of nanoparticles through electrodeposition method.The nanoparticles we have selected for coating are Cerium Oxiode Nanoparrticles.

Synthesis Of CeO2 Nps by Wet chemical Reduction Method:

• Take 0.1M solution of  cerium nitrate hexahydrate
• Stirrer for 3 h at 80oC
• Add 0.3M NaOH solution dropwise ( as a result pinkish Precipitates produced)
• The solution then centrifuged at 2000 rpm for 15 min followed by washing with deionized water and methanol.
• Finally, it was dried at 90°C for 3 hours in oven and annealed in the muffle furnace at 270 °C for 4 h.

Now Coating of Cerium Oxide Nanoparticles On 316L-SS through Electrodeposition Method.  2 sheets were used Zinc plate and 316L-SS sheet (as anode and cathode).

In last After done with coating we will go with characterization Techniques/Electrochemical Study.

Techniques:                                                                                                                                            

1. Spark Spectroscopy For elemental analysis of 316LSS
2.  Scanning Electron Microscopy (SEM)

This test is conducted to understand the surface morphology of coating.

1. X-ray Diffraction (XRD)

This test is conducted for the Phase analysis of Cerium Oxide coating on 31SL-SS.

Electrochemical Study:

 This is for corrosion study it includes two tests:

1. Tafel Polarization
2.  2- Electrochemical Impedance Spectroscopy

                                                                                                                                                                                   

Benefits of the Project

The key benefits of Coating CeO2 Nanoparticles on Dental Implants(316L-SS):

• It will Enhance Osseointegration.
• Exerts Antibacterial Effect.
• Promotes Cell Proliferation.
• CeO2 Nps have potential in improving healing process.
• Promotes Bone Regeneration on implant surface and enhance Vascularization.
• Make dental implant long Term stable.

Technical Details of Final Deliverable

Designing an implant and modifying its success by means of suitable coating of nanomaterials is a great addition to pre-existing list of implants being designed by Biomedical Engineer.

Coated dental Implant with nanoparticles having good biocompatiblity, antibacterial properties will enhance osseointegration and promotes cell proliferation and one can get easily treated eduntiliasm(tooth loss).  

Final Deliverable of the Project Hardware SystemCore Industry MedicalOther Industries Others Core Technology Wearables and ImplantablesOther Technologies OthersSustainable Development Goals Good Health and Well-Being for PeopleRequired Resources

Item Name	Type	No. of Units	Per Unit Cost (in Rs)	Total (in Rs)
			Total in (Rs)	80000
Characterization Techniques(XRD,SEM,Spark spectroscopy) per sample.	Equipment	4	8750	35000
Electrochemical Study Per sample	Equipment	4	8750	35000
316L SS plate, Zinc plates , Chemicals and Outdoor Visits of sample .	Miscellaneous	5	2000	10000