Design of nano_implant for musculoskeletal tissue and cartilage regeneration

Incorporation of functionalised and modified nanostructures in various biomedical applications has generated considerable research interest in recent years. The applications of nanotechnology in medicine and biomedical engineering are vast and spans areas such as implant and tissue engineering, diag

Project Title

Design of nano_implant for musculoskeletal tissue and cartilage regeneration

Project Area of Specialization

Biomedical Engineering

Project Summary

Incorporation of functionalised and modified nanostructures in various biomedical applications has generated considerable research interest in recent years. The applications of nanotechnology in medicine and biomedical engineering are vast and spans areas such as implant and tissue engineering, diagnosis and therapy. The present scenario demands design and synthesis of Nanotechnology based solution to the needs of biological problems, so that these biological abnormalities can possibly be addressed at cellular level. This can help are early cure and localized therapies will help in fast recovery with increased efficacy. In this project we are going to design a Nano technology based implant for musculoskeletal tissues and cartilage regeneration. The project will demonstrate the process of encapsulation of Beta Tri-calcium Phosphate in Poly Lactic Acid (PLA (A polymer with degradation time of 42-72 days...link) to synthesize the said Nano implant, we will be using the method of electrospinning. The final deliverable will be drug carrying nanofiber patch implantable during surgical procedure carried to repair the damage, due to some accident resulted in bone or cartilage deficit.

Project Objectives

PROJECT OBJECTIVES:

The objective of this research is to bring about a nanotechnology based drug carrier that can help improve the bioavailability of drug by using a  Biaxial Electrospinning Method for synthesis of implantable Nano-patch.

Project Implementation Method

IMPLEMENTATION METHOD:

• First to take a beaker.
• Then take chloroform and acetone for solvent in 2:1.
• Then take 9% wt% of PLA particles.
• Dissolve in solution with the help of magnetic stirrer for 5hr at the room temperature till a homogenous solution is obtained.

FOR ELECTROSPINING:

• Solution filled in syringes (20ml) with a capillary (0.7mm inner diameter)
• Give 16kv applied to the electrospinning process with distance of 12cm between the syringe tip and collector.
• The feed rate of the electrospinning was kept at 0.5ml/hr by a micro-infusion pump.
• In the course of electrospinning the solvent evaporated and only left nanofibers attached on the aluminum foil forming a nanofiber membrane.
• flow chart:
• 

Benefits of the Project

BENEFITS: 

Tissue regeneration is very fast growing scientific area in this era and used to repair damaged tissues and cartilage by using cell and/or combinations of cells with biomaterials and/or biologically active molecules and helps to produce materials which very much resembles to body's native tissue/tissues. Tissue engineering is the connecting discipline between engineering materials science, medicine and biology. In typical Tissue regeneration process repairing materials  are seeded on biomimicked scaffold providing carrier surfaces. “Novel biomimetic scaffold” and “Modern technology” been developed for enhanced bioavailability of repairing agents at site. Using Nano synthesis techniques such biodegradable Nanoimplants will help improve the efficacy and through increased bioavailability and more surface-to-volume ratio precision and expeditious regeneration is achieved. There are several benefits of using nanosynthesis techniques for tissue engineering. Nanotechnology can be used to create nanofibers, nanopatterns and controlled-release nanoparticles with applications in tissue engineering, for mimicking native tissues since biomaterials to be engineered is of nanometre size as in human body.

Technical Details of Final Deliverable

TECHNICAL DETAILS  OF FINAL DELIVERAABLE:

The deliverable Nano-patch is a next-generation drug delivery platform that consists of an array of millions of Nanofibers loaded with Beta Tri Calcium Phosphate able to release the drug from Nanofibers  over the period of 45 days to 70 days. The Nano-patch will Biodegradable, Biocompatible and GRAS (Generally Regarded as Safe) graded a sper FDA specifications. 

Final Deliverable of the Project

Hardware System

Core Industry

Health

Other Industries

Medical

Core Technology

Wearables and Implantables

Other Technologies

NeuroTech

Sustainable Development Goals

Good Health and Well-Being for People

Required Resources

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